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Dermal Fillers
What is a Granuloma and What Causes It?
A granuloma is your body's immune response to a foreign body. There are substances that are more likely to cause granuloma formation and substances that are less likely to form granulomas. Most modern injectables (especially the HA injectables) typically do not form granulomas as they are minimally stimulating to your immune system. It is not impossible though. Discuss the lumps with your injector. They will likely recommend observation and time. The lumps will likely resolve.
Clinical Context
Granulomas form when the immune system walls off a substance it can't break down. Hyaluronic acid fillers are metabolized naturally and rarely trigger this reaction. Older or permanent materials, such as silicone or PMMA, are more likely to cause a granuloma because the body treats them as a lasting foreign object. Injection technique, including placing filler too superficially, can also play a role. If you notice a lump after filler, your injector can help determine whether it's a normal response or needs further treatment.
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