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Botox for Sweating - How Long Do the Effects Last?

In my practice I have successfully used Botox to treat individuals with excess sweating. Botox works by blocking the nerve chemical that tells sweat glands to turn on, so instead of relaxing a muscle like it does for wrinkles, it quiets the glands themselves in the area treated, whether that's the underarms, palms, or soles. Most patients notice a real drop in sweating within a few days to a week, and that reduction stays local to the treated area.

There is some variability in the length of relief patients can get but most of my patients have seen 6 months to 1 year. As the effect wears off, sweating gradually returns to baseline rather than stopping suddenly, so you'll have a good sense of when it's time to schedule another treatment. If you notice no improvement at all after treatment, that's worth discussing at a follow up visit.

Clinical Context

Botox for sweating targets a different pathway than Botox for wrinkles. Instead of relaxing muscles, it blocks the nerve chemical (acetylcholine) that signals sweat glands to activate. It's injected in a grid pattern across the underarms, palms, or soles rather than at a few muscle points. Because it works locally in the treated area, it won't reduce sweating happening elsewhere on the body from unrelated triggers.

Answered by Dr. Steven Williams, President Emeritus of ASPS

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