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Can someone Become Hypersensitive to Botox?
Five years ago, I tried Botox migraines and cosmetic use. I liked the results for cosmetic but the jury was still out for migraines. Last year, on March, I decided to try a "migraine protocol” my neurologist recommended. Unlike the 20-27 units I was getting for cosmetic reasons, the protocol was for 100 units (all over the head). I experienced new and very scary side effects that included eye droop and swelling of the lids. One year has passed and I went to my dermatologist who has been administering the Botox for the past 5 years without problems. That night, I could feel the tingling in my face and left eye which was most effected before. Today, there was more eye drooping, burning eyes, and swollen lids. I have decided that I can no longer tolerate Botox. Am in danger of the eye droop not correcting itself since this is the second time? I received 21 units in the forehead and 12 units between the brows. Thank you!
Sensitivity to Botox
Thanks for your question - I have not seen acquired Botox sensitivity described in the literature. Eyelid drooping after Botox injection can happen in the medication is administered in the wrong area or if you have a significant amount of lid skin excess that your frontalis muscle is working to keep out of your line of site. You should discuss these issues with your injector. Consider speaking to another board certified dermatologist or plastic surgeon with experience in injecting. And certainly consider other techniques for management of migraines since you have had issues with this type of treatment. I hope this helps.
Botox (onabotulinumtoxinA) is an FDA-approved neuromodulator that temporarily relaxes targeted facial muscles to reduce the appearance of dynamic wrinkles. It works by blocking the release of acetylcholine at the neuromuscular junction. Results typically appear within 3–7 days and last 3–4 months, though some patients report longer duration with consistent treatment. Common treatment areas include the glabella (frown lines), forehead, and lateral canthal lines (crow’s feet). Dosing is measured in units and varies by treatment area and muscle mass.
Selecting a board-certified plastic surgeon who is a member of the American Society of Plastic Surgeons ensures your surgeon has met the highest professional standards.

